Monica Del-Rio-Vellosillo; Elena Rubio-Velazquez; Raquel Agustina Góngora-Rodríguez; Dolores Párraga-Muñoz; Vicente Zanon-Moreno; Maria D. Pinazo-Duran; Juan Jose Zafra-Perez; Jose Javier Garcia Medina

Retinal thickness and vascular parameters estimated by OCT and OCT angiography in autism spectrum disorder

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Purpose : The aim of this study was to compare retinal thicknesses and vascular parameters between autism spectrum disorder (ASD) and neurotypical (NT) individuals.

Methods : 14 eyes of 14 high-functioning ASD subjects and 14 eyes of 14 age- and sex-matched NT participants underwent 4 scans with the device Cirrus HD-OCT 5000 (Zeiss): macular cube, optic nerve cube, macular and optic nerve head (ONH) OCT angiography (OCT-A). Concerning OCT, thickness of full retina in 9 sectors of macular ETDRS pattern and peripapillary retinal nerve fiber layer (pRNFL) in 4 quadrants and 12 clock-hour sectors were considered. Vessel density and capillary perfusion density in 9 sectors were measured using macular OCT-A. ONH OCT-A estimated perfusion density and flux index in 4 peripapillary quadrants. Comparions between groups of these parameters were performed using U Mann-Whitney test.


Results : ASD subjects showed higher ONH perfusion density and lower ONH flux index at the inferior quadrant when compared with NT individuals (p<0.05). Plus, a trend towards higher macular thickness, higher pRNFL thickness at inferior clock-hour sectors and higher macular vessel density and perfusion was observed in ASD.

Conclusions : Retinas of ASD subjects may present some structural and vascular differences when compared with retinas of NT individuals.

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